Noroxin

What Noroxin Is

Noroxin is a brand name of norfloxacin, an antibiotic of the fluoroquinolone class. It is used to treat various bacterial infections: gynecological infections, infections of the urinary tract and bladder, prostate gland inflammation, some STDs (e.g. gonorrhea), eye infections. However, norfloxacin is not effective against syphilis; it may even mask or delay its symptoms. Norfloxacin is normally administered orally or as eye drops in ophthalmology.

Recommendations for Use, Dosage and Overdose

The dosage of Noroxin varies depending on the disease, degree of its severity, and age and general health of the patient. Therefore, it can be different for different patients. Follow your prescription or the instructions on the label. The information provided here only shows the average doses of the drug for a general overview.

Noroxin pills normally come in 400 mg dosage. Adults are usually prescribed 400 mg 2 times a day (every 12 hours) for the course of 3 to 21 days, depending on the infection or the disease. Prostatitis treatment, for example, usually takes about 28 days. For gonorrhea, a single oral dose of 800 mg is given.

The doses for children are different and must be determined by the pediatrician. Swallow the pills whole with a full glass of water. Generally, increased fluids intake is recommended while on Noroxin treatment. Extra water can help to prevent some side effects of norfloxacin.

Normally, norfloxacin is taken 1 hour before or 2 hours after a meal. Avoid dairy and caffeine (contained in coffee, chocolate, soda, etc.) while on norfloxacin. The antibiotic may cause caffeine to excrete from your body longer than usual.

Take Noroxin exactly as prescribed by your doctor. Do not change the dose, interval or course of treatment on your own!

Before starting the treatment, read the instruction sheet carefully and follow the directions there. If you do not understand something or have any questions, check with your doctor!

Keep taking the drug for the full treatment course, even if your symptoms quickly improve soon after the first few doses and you feel better. Your infection may not be fully eradicated if you stop using the drug prematurely, which puts you at a risk of developing an antibiotic-resistant infection.

If you accidentally miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed one and then come back to your regular schedule. Do not take two doses at a time. In case of overdose, seek immediate medical attention or call a poison helpline.

Precautions and Contraindications

When deciding whether to start norfloxacin treatment, your doctor has to weigh all the risks associated with taking the medicine against the potential benefit. For this decision to be adequate, provide your physician with the full and accurate information about your medical history, drugs you are taking, known allergies, pregnancy or breastfeeding.

Noroxin is generally contraindicated for patients with the history of tendon rupture, tendonitis, or hypersensitivity or allergy to fluoroquinolones.

Inform your doctor if you have ever had problems with tendons or allergic reactions to Noroxin, other antibiotics or any other known allergies to foods, chemicals, or animals.

Noroxin is not advised for children due to the lack of appropriate studies on the relation of age to the effects of norfloxacin in this age category. Therefore, the safety and efficacy are unknown.

The studies have not shown geriatric-specific issues associated with norfloxacin intake, therefore, it is safe to use for elderly patients. However, such patients have higher chances to develop heart or kidney problems or severe tendon problems (even rupture). Hence, caution and dose adjustment are advised.

Norfloxacin has been confirmed in studies to rapidly penetrate the blood-placenta and blood-milk barriers and be extensively transported to the fetus. Due to the risk of birth defects and spontaneous abortions, norfloxacin is contraindicated during pregnancy, especially during the first trimester. Generally, there are safer alternatives to norfloxacin. The treatment during pregnancy should be carried out only when potential benefits for the mother outweigh the risks for the child.

Fluoroquinolones are passed to the nursing child through mother’s milk, which can lead to an adverse reaction in a child. Studies for determining infant risk during breastfeeding are insufficient. Therefore, it is recommended to temporarily discontinue breastfeeding while on norfloxacin treatment.

Interactions with Other Drugs and Substances

Tell your physician and pharmacist about any prescription and over-the-counter medications you are taking, especially other antibiotics, blood thinners (anticoagulants) such as warfarin (Coumadin), cimetidine (Tagamet), cancer chemotherapy agents, cyclosporine (Neoral, Sandimmune), caffeine-containing medicines (Vivarin, NoDoz), nitrofurantoin (Macrodantin), sucralfate (Carafate), probenecid (Benemid), theophylline (Theo-Dur), vitamins, and herbal products.

Do not take non-steroidal painkillers and anti-inflammatory drugs (NSAIDs), such as ibuprofen, while taking norfloxacin treatment.

Norfloxacin is known to interact with substances containing iron or zinc. For this reason, do not take the drug simultaneously with antacids (Maalox, Mylanta), didanosine (Videx), iron or zinc supplements or vitamins. These medicines may keep norfloxacin from working properly. Take them in 2-hour intervals with the antibiotic.

It is also advised to avoid consumption of dairy products. Norfloxacin may inactivate live bacterial vaccines, like oral typhoid vaccine. Therefore, it is advised to put off vaccination until after the treatment is finished.

Side Effects

Norfloxacin can cause serious allergic reactions: rash, hives, itching, short breathing, trouble swallowing, swelling. Some of them, such as anaphylaxis, can be life-threatening. Serious skin reactions include skin pain, blistering, peeling, red spots, rash, sores, fever or chills. Among worrisome symptoms that relate to liver, there can be abdominal pain, dark urine, clay-colored stools, or yellow eyes or skin. Seek immediate medical help if you are experiencing any of the above-mentioned symptoms.

Norfloxacin may cause dizziness, drowsiness, and unclear thinking. Refrain from driving or operating heavy machinery to avoid accidents. If these reactions get too bothersome, consult your doctor. Tell your healthcare provider right away if you have noticed any unusual mood or behavior changes: anxiety, confusion, depression, convulsions, sensory impairment, severe headache, insomnia.

Diarrhea is a common side effect associated with antibiotic treatment. Usually, it goes away by itself, but sometimes it can be too severe or may persist for up to 2 months after the treatment. If your diarrhea continues for a long time or gets worse, consult your doctor. You may be prescribed some anti-diarrhea medications.

Tell your doctor right away if you experience numbness, tingling, or burning in your extremities. These may be the signs of peripheral neuropathy, which requires medical attention.

Norfloxacin and other fluoroquinolones are often associated with tendon complications such as inflammation or even tearing. The risk is even higher for patients over 60, receiving steroid medicines (dexamethasone, prednisone, prednisolone, or Medrol), patients with severe kidney problems or previous history of tendon problems (e.g. rheumatoid arthritis), patients with an organ transplant. If you experience pain or swelling in a tendon or joints, inform your doctor immediately. Refrain from hard exercise and intense physical activity during the treatment.

Norfloxacin can increase sensitivity to sunlight, which can result in sunburns. Try to stay out of direct sunlight, wear protective clothing, and apply sunscreen with SPF 15+. Avoid tanning beds, too.

It is highly important for your doctor to check your progress during Noroxin treatment to make sure the medication is working correctly and see if there is a need for adjustments. Some medical tests may be run to monitor the situation.

Keep in Mind

Before starting Noroxin treatment, inform your doctor fully and accurately about your medical history, any known allergies, drugs or substances you are taking, pregnancy or breastfeeding. This will help to reduce any severe reactions or adverse reactions to the minimum.

Take Noroxin only for the indications prescribed and in strict accordance with your doctor’s orders. Do not share it with other people, even if their symptoms are identical to yours. Just like other antibiotics, Noroxin does not treat viral infections like flu or common cold.

Do not stop the treatment on your own; take the drug for the full prescribed course. The symptoms may improve sooner, but the infection might not yet be cleared out. This increases the risk of antibiotic resistance. Do not skip doses either.

Store Noroxin at room temperature away from moisture, heat, direct sunlight and out of children’s reach. Dispose of any expired leftovers; do not take expired medication. Inform your doctor at once about any bad reactions to the drug or seek urgent medical help.